方法一:

public void TransformToPixels(double unitX,
                              double unitY,
                              out int pixelX,
                              out int pixelY)
{
    using (Graphics g = Graphics.FromHwnd(IntPtr.Zero))
    {
        pixelX = (int)((g.DpiX / 96) * unitX);
        pixelY = (int)((g.DpiY / 96) * unitY);
    }

    // alternative:
    // using (Graphics g = Graphics.FromHdc(IntPtr.Zero)) { }
}

方法二(WIN32API方式):

[DllImport("gdi32.dll")]
public static extern int GetDeviceCaps(IntPtr hDc, int nIndex);

[DllImport("user32.dll")]
public static extern IntPtr GetDC(IntPtr hWnd);

[DllImport("user32.dll")]
public static extern int ReleaseDC(IntPtr hWnd, IntPtr hDc);

public const int LOGPIXELSX = 88;
public const int LOGPIXELSY = 90;

public void TransformToPixels(double unitX,
                              double unitY,
                              out int pixelX,
                              out int pixelY)
{
    IntPtr hDc = GetDC(IntPtr.Zero);
    if (hDc != IntPtr.Zero)
    {
        int dpiX = GetDeviceCaps(hDc, LOGPIXELSX);
        int dpiY = GetDeviceCaps(hDc, LOGPIXELSY);

        ReleaseDC(IntPtr.Zero, hDc);

        pixelX = (int)(((double)dpiX / 96) * unitX);
        pixelY = (int)(((double)dpiY / 96) * unitY);
    }
    else
        throw new ArgumentNullException("Failed to get DC.");
}

方法三(不推荐):

读取注册表HKLM\SOFTWARE\Microsoft\Windows NT\CurrentVersion\FontDPI 的DWORD值

方法四(WPF方式):

public void TransformToPixels(Visual visual,
                              double unitX,
                              double unitY,
                              out int pixelX,
                              out int pixelY)
{
    Matrix matrix;
    var source = PresentationSource.FromVisual(visual);
    if (source != null)
    {
        matrix = source.CompositionTarget.TransformToDevice;
    }
    else
    {
        using (var src = new HwndSource(new HwndSourceParameters()))
        {
            matrix = src.CompositionTarget.TransformToDevice;
        }
    }

    pixelX = (int)(matrix.M11 * unitX);
    pixelY = (int)(matrix.M22 * unitY);
}

性能方面,方法四要比方法二快两倍